Theory of endocrine dysfunction or neuroendocrine theory of aging 70
years of the 20th century one of the major theories of aging.
Generally believed that multicellular organisms secrete nerve function
within the hair and its growth, development, maturation and aging has
a very close relationship. On the one hand the following hypothalamic
pituitary glands - target organ of the neuroendocrine system
consisting of the following body structure machine high degree of
unity and highly flexible control hub; the other hand, aging of the
neuroendocrine system is voluntary, and nerve cells and clusters of
genes related to endocrine cells . Studies have shown that
physiological and biochemical processes of aging and age-related
neuroendocrine system loss adjuster, is closely related to degradation
and failure, but these changes are the result of aging or because
there is no conclusion. Aging is a complex variety of factors produced
by biological phenomena, although the aging of the internal genetic
factors (which determines the maximum bio-life) can not be ignored.
This mainly refers to environmental factors within the body
environment and the stability of the environment. The stability of the
environment in the body mainly by regulation of the neuroendocrine
system, its regulation is complex, involving a major regulator of body
hub (that is, from the hypothalamic pituitary glands - composed of the
target cell neuroendocrine network) in the multi-link (including nerve
and gland cells the process of molecular biology, cell number, changes
in receptor density and the letter from the transmission process,
hormone secretion and rhythm, the sensitivity of the feedback control
loop, and the nervous system regulation of endocrine system function)
fine-tuning, that barriers of any part of the body's endocrine
disorders of, causing disorder within the environment, eventually
leading to aging and death of the body.
Organism's development, maturation, reproduction and aging controlled
by genes is actually a procedural process, the characteristics and
processes of aging in different individuals or between different
species are quite different, and sometimes the same strains within the
family of each generation but there is a strong consistency. Cellular
and molecular composition of the same or different families of
different types of individuals to lead a different life, which shows
the slight difference on the genetic information lead to tissue
adaptability to different habitat differences. This is different in
different organisms in different ecological environments formed by
long-term survival. This strong program of the endocrine system by
controlling the process of cell growth / differentiation control in a
certain environment to survive the longest, and its optimal changes in
the environment (including economic conditions, occupation, and
ideology, living conditions and lifestyle, environmental pollution,
noise and drugs and food, etc.) is bound to cause endocrine regulatory
function of the difference in accuracy, and thus affect the cell
surface metabolism. Organisms during aging genes programmed to express
the reasons for cell metabolism, and thus the endocrine system
disorders caused by disorders of cell metabolism may be an important
cause of cell aging.
Aging, "the pace of regulators," the doctrine that the memory in the
control aging brain cells, these cells can not determine the start of
aging, but can make the aging process has been accelerated or slowed
down. Most of those who think that this control the aging process of
cells mainly located in the hypothalamus and limbic system, which
regulate the body parts of the endocrine activity through the
pituitary, is the control center of a stable internal environment,
which is likely to be age-related changes into the "aging clock" .
In recent years, medical experts noted in particular growth hormone
decline with age and significant phenomenon, and the corresponding
symptoms of aging also appeared, such as the degradation of muscle
atrophy - fat increases, at present, many doctors in the United States
had used growth hormone to control the speed of aging.
Clear from the Commission on the Aging of the endocrine system is very
complex and not yet fully clear, but certainly in the aging process of
the endocrine system plays an important role. Therefore, measures to
understand the aging of the neuroendocrine system, and effective
prevention and treatment of senile diseases has important theoretical
and practical significance.
